The Blues menderita kekalahan 1-0 melawan Borussia Dortmund di pertandingan sebelumnya dan harus memperbaiki performa di kancah domestik kali ini.
Head to Head Chelsea vs Southampton
31/08/22: Southampton 2-1 Chelsea
09/04/22: Southampton 0-6 Chelsea
27/10/21: Chelsea 1-1 Southampton
02/10/21: Chelsea 3-1 Southampton
20/02/21: Southampton 1-1 Chelsea